1094º Dia

Olá Blogueir@s!

Por aqui as chatices continuam, o vazamento do banheiro está sem solução e o meu braço está com um aspecto muito melhor, mas, DÓI! :(

Continuo no anti-inflamatório e estou dando banhos de permanganato.

Agora a pílula de esperança do dia: San Antonio Breast Câncer Symposium.  Abaixo, copiei a lista de trabalhos sobre terapias alvo de tratamento estratégico para câncer de mama por sobrexposição ao HER2. Destaco os diversos trabalhos relativos à resistência ao Trastuzumab (Herceptin) e ao Lapatinibe (Tykerb), tomara que tenham descoberto algo relevante para potencializar os remedinhos mágicos que não têm funcionado plenamente em mim e em outras amigas aqui do blog.

Um ótimo dia para todo mundo, amanhã volto com mais novidades de San Antonio! A lista dos trabalhos de Terapia Alvo que citei acima está em seguida.

Margareth

P1-12-01	Pregnancy during and Following Adjuvant Trastuzumab in Patients with HER2-Positive Breast Cancer: An Analysis from the HERA Trial (BIG 01-01) Azim, Jr HA, Metzger-Filho O, de Azambuja E, Loibl S, Focant F, Gresko E, Procter M, Piccart-Gebhart M. Institut Jules Bordet, Brussels, Belgium; German Breast Group, Frankfurt, Germany; F. Hoffmann-La Roche, Basel, Switzerland; Frontier Science, Kincraig, United Kingdom.
P1-12-02	Patient-Reported Outcomes (PROs) from a Randomized Phase II Study (TDM4450g/BO21976) of Trastuzumab Emtansine (T-DM1) vs Trastuzumab Plus Docetaxel (HT) in Previously Untreated HER2-Positive Metastatic Breast Cancer (MBC) Bianchi GV, Kocsis J, Dirix L, Torigoe Y, Lalla D, Tong YB, Guardino AE, Hurvitz SA. Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Semmelweis University Budapest, Budapest; Sint-Augustinus, Antwerp; Genentech; UCLA/Translational Oncology Research International.
P1-12-03	Combined Targeting of the PI3K Pathway and HER2 Overcomes Acquired and De Novo Trastuzumab Resistance O'Brien NA, McDonald K, Von Euw E, Conklin D, Kalous O, Di Tomaso E, Finn RS, Slamon DJ. University of California at Los Angeles, Los Angeles, CA; Novartis-Oncology, Cambrige, MA.
P1-12-04	EBP50 - A Novel Biomarker for Resistance to Endocrine and HER2-Targeted Therapies in Breast Cancer Gu G, Covington KR, Fernandez NM, Ando' S, Fuqua SAW. Baylor College of Medicine, Houston, TX; University of Calabria, Arcavacata di Rende, Cosenza, Italy.
P1-12-05	Complete Pathological Response of Ductal Carcinoma In Situ after Treatment with Neoadjuvant Herceptin Chalmers CR, Mallon EA, Touqan N, Horgan KJ, MacPherson I, Doughty JC. The Western Infirmary, Glasgow, Scotland, United Kingdom; Leeds General Infirmary, Leeds, Yorkshire, United Kingdom.
P1-12-06	The Role of MAPK and PI3K/AKT/mTOR Signaling in Innate Lapatinib Resistance McDermott M, O'Brien N, McDonald K, Crown J, O'Donovan N, Slamon D. Dublin City University, Glasnevin, Dublin 9, Ireland; University of California Los Angeles, Los Angeles, CA; St. Vincents University Hospital, Elm Park, Dublin 4, Ireland.
P1-12-07	Pharmacokinetics (PK) of Trastuzumab Emtansine and Paclitaxel or Docetaxel in Patients with HER2-Positive MBC Previously Treated with a Trastuzumab-Containing Regimen Lu D, Modi S, Elias AD, Agarwal P, Yi J-H, Guardino AE, Althaus BL, Girish S. Genentech, South San Francisco, CA; Memorial Sloan-Kettering Cancer Center, New York, NY; University of Colorado, Aurora, CO.
P1-12-08	Induction of Adhesion Molecules on Target Cells Maximizes Antibody-Dependent Cell-Mediated Cytotoxicity of Anti-Her2 Therapeutic Antibody with High Fucose Glycan Jia X, Wong P-Y, Gazzano-Santoro H. Genentech Inc., South San Francisco, CA.
P1-12-09	Safety and Efficacy of Neratinib in Combination with Capecitabine in Patients with ErbB2-Positive Breast Cancer Saura C, Garcia-Saenz JA, Xu B, Harb W, Moroose R, Pluard T, Kiger C, Germa C, Wang K, Kim S-B. Breast Cancer Unit, Vall d'Hebron University Hospital, Barcelona, Spain; Hospital Clinico San Carlos, Madrid, Spain; Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China; Horizon Oncology Center, Lafayette, IN; Florida Hospital Cancer Institute, Orlando, FL; Washington University School of Medicine, St. Louis, MO; Pfizer Global Research and Development, Paris, France; Pfizer Inc, Pearl River, NY; Asan Medical Center, Seoul, Korea.
P1-12-10	Phase II Study Evaluating Lapatinib (L) in Combination with Albumin Bound Paclitaxel (ab-Pac) in Women Who Have Received 0-1 Chemotherapy Regimen for HER2 Overexpressing (HER2+) Metastatic Breast Cancer (MBC) Yardley DA, Hart L, Bosserman L, Saleh MN, Waterhouse DM, Richards P, Hagan MK, DeSilvio ML, Mahoney JM, Nagarwala Y. Sarah Cannon Research Institute; Tennessee Oncology, PLLC; Florida Cancer Specialists; Willshire Oncology Medical Group; Georgia Cancer Specialists; Oncology & Hematology Care, Inc.; Virginia Cancer Care; Oncology & Hematology Associates of SW; GlaxoSmithKline, Collegeville, PA.
P1-12-11	Neoadjuvant Chemotherapy-Trastuzumab Versus Neoadjuvant Chemotherapy Followed by Post-Operative Trastuzumab: A Multicentre Study Palmieri C, Yan K, Owadally W, Shah D, Gojis O, North B, Riddle P, Ahmad R, Lewanski C, Coombes RC, Cleator S, Howell S, Beresford M. Imperial College Healthcare NHD Trut, London, United Kingdom; Bristol Haematology and Oncology Centre, Bristol, United Kingdom; Third Faculty of Medicine, Charles University, Prague, Czech Republic; Imperial College London, London, United Kingdom; The Christie NHS Foundation Trust, Manchester, United Kingdom.
P1-12-12	Withdrawn
P1-12-13	Comparative Pharmacokinetics (PK) of Trastuzumab Emtansine (T-DM1) in Patients Who Have or Who Have Not Received Prior Treatment for Human Epidermal Growth Factor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) Wang B, Conte P, Casanova LA, Vinholes JJdF, Saad OM, Yi J-H, Gupta M, Song C, Olsen SR, Perez EA, Girish S. Genentech, South San Francisco, CA; University of Modena and Reggio Emilia, Modena, Italy; Instituto Oncológico Miraflores, Lima, Peru; CliniOnco, Porto Alegre, Brazil; Mayo CLinic, Jacksonville, FL.
P1-12-14	Genetic Ablation or Pharmacological Inhibition of Autophagy Suppresses Intrinsic Resistance of Breast Cancer to HER2-Targeted Therapies Cufí S, Oliveras-Ferraros C, Vazquez-Martin A, Sauri-Nadal T, Del Barco S, Martin-Castillo B, Lopez-Bonet E, Menendez JA. Catalan Institute of Oncology, Girona, Catalonia, Spain; Girona Biomedical Research Institute (IDIBGi), Girona, Catalonia, Spain; University Hospital of Girona Dr. Josep Trueta, Girona, Catalonia, Spain.
P1-12-15	Adjuvant Trastuzumab Effect on HER2-Positive Breast Cancers According to Hormonal Receptor (HR) Status: Crosstalk between ER and EGFR/HER2 Pathway May Prevent Trastuzumab from Improving Outcomes in HER2-Positive and HR-Positive Breast Cancers Park YH, Cho EY, Lee JE, Nam SJ, Yang JH, Ahn JS, Im Y-H. Samsung Medical Center.
P1-12-16	HER-2 Testing and Treatment - Is Age a Factor? Singh JK, Ewing K, Howell S, Howe M, Cramer A, Bundred NJ. School of Cancer and Enabling Sciences, University of Manchester, Paterson Institute for Cancer Research, Manchester, United Kingdom; Univerisity Hospital of South Manchester, Wythenshawe Hospital, Manchester, United Kingdom; The Christie NHS Foundation Trust, Manchester, United Kingdom.
P1-12-17	Fluorescent In Situ Hybridization Evaluation of HER2 Status in Tumors with Chromosome 17 Polysomy Pietri E, Medri L, Farolfi A, Sarti S, Maltoni R, Cecconetto L, Ibrahim T, Paioli A, Serra L, Amadori D, Rocca A. Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola, (FC), Italy; Morgagni-Pierantoni Hospital, Forlì, (FC), Italy.
P1-12-18	Change in HER2 Status in HER2 Positive Operable Breast Cancer Patients Treated with Neoadjuvant Chemotherapy with or without Anti-HER2 Therapy: Analysis of Two Consecutive Cohorts Barbieri E, Piacentini F, Dieci MV, Ficarra G, Bettelli S, Conte P, Guarneri V. Modena University Hospital, Modena, Italy.
P1-12-19	Phase I Study of Single Agent Trastuzumab Emtansine in Japanese Patients with Human Epidermal Growth Factor Receptor2 (HER2)-Positive Metastatic Breast Cancer (JO22591) Aogi K, Ando M, Iwata H, Hara F, Matsubara M, Fujiwara Y. National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan; National Cancer Center Central Hospital, Chuo-ku, Tokyo, Japan; Chuo Hospital Aichi Cancer Center, Nagoya, Aichi, Japan; Chugai Pharmaceutical Co. Ltd, Chuo-ku, Tokyo, Japan.
P1-12-20	The Safety and Tolerability of Vorinostat in Combination with Lapatinib in Advanced Solid Tumors Chumsri S, Tait NS, Medeiros MM, Bauer KS, Betts K-MT, Lewis JC, Bao T, Feigenberg SJ, Kesmodel SB, Stearns V, Edelman MJ, Sausville EA, Tkaczuk KHR. University of Maryland Greenebaum Cancer Center, Baltimore, MD; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; University of Maryland, Baltimore, MD.
P1-12-21	Adjuvant Trastuzumab Treatment without Adjuvant Chemotherapy in Early Breast Cancer Dall P, Koch T, Lenzen G, Kuhn T, Hielscher C, Reichert D, Maasberg M, Ehscheidt P, Eustermann H, Fischer G. Städt. Klinikum, Lüneburg, Germany; Klinikum Nürnberg-Nord, Nürnberg, Germany; Praxis, Osnabrück, Germany; Brustzentrum, Stuttgart, Germany; Praxis, Stralsund, Germany; Praxis, Westerstede, Germany; Praxis, Mayen, Germany; Praxis, Neuwied, Germany; WiSP, Langenfeld, Germany; Landkreis Mittweida Khs., Mittweida, Germany.
P1-12-22	Impact on Survival of the Level of HER2/neu Gene Amplification in Patients with HER2-Positive (HER2+) Advanced Breast Cancer (AdvBrCa) Treated with Trastuzumab (H) Gullo G, Bettio D, Zuradelli M, Masci G, Giordano L, Bareggi C, Salvini P, Runza L, Santoro A. St Vincent's University Hospital, Dublin, Ireland; Istituto Clinico Humanitas, Rozzano, MILano, Italy; Humanitas Cancer Centre, Rozzano, MILano, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Cliniche Humanitas Gavazzeni, Bergamo, Italy.
P1-12-23	HER4 Coexpression Is Associated with Improved Recurrence Free Survival in HER2-Positive, Herceptin Treated Patients Brockhoff G, Machleidt A, Piendl G, Seegers S, Sassen A, Diermeier-Daucher S, Buchholz S, Ortmann O. University Medical Center Regensburg, Regensburg, Bavaria, Germany.
P1-12-24	Adherence and Persistence with Lapatinib in Women with Metastatic Breast Cancer Who Were Previously Treated with Trastuzumab Delea TE, Kartashov A, Sharma PP. Policy Analysis Inc. (PAI), Brookline, MA; GlaxoSmithKline, Philadelphia, PA.
P1-12-25	Evaluation of PTEN, EGFR and Ki67 Expression as Predictors of Response to a Trastuzumab-Containing Neoadjuvant Chemotherapy Regimen in a HER-2 Over-Expressing Locally Advanced Breast Cancer (LABC) Trial Ho J, Turashvili G, Hayes M, Gelmon KA, Ellard SL, Macpherson N, Pansegrau G, Chia SK. British Columbia Cancer Agency, Vancouver, BC, Canada; British Columbia Cancer Research Centre, Vancouver, BC, Canada; British Columbia Cancer Agency, Kelowna, BC, Canada; British Columbia Cancer Agency, Victoria, BC, Canada; British Columbia Cancer Agency, Surrey, BC, Canada.
P1-12-26	Global Patterns of Care for HER2/neu Overexpressing Breast Cancer Y. Chavarri-Guerra, P. Liedke, H. Symecko, B. Moy, M. Higgins, J. St. Louis, D. Finkelstein, P. Goss. Massachusetts General Hospital - Avon International Breast Cancer Program, Boston, MA.